Clinical aspects associated with syndromic forms of Orofacial Clefts in a Colombian population

Objectives: To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nestedseries of cases. Methods: A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, and distribution of Orofacial Clefts according to sex and affected-side were determined. Odds ratios were calculated as measures of association between syndromic forms and antenatal high-risk conditions, preterm birth and comorbidities. A total of three hundred and eleven patients with Orofacial Clefts were assessed in a 12-month period. Results: The most frequent type of Orofacial Clefts was cleft lip and palate, this type of cleft was more frequent in males, whereas cleft palate occurred more often in females. The most common cases occurred as non-syndromic forms. Aarskog-Scott syndrome showed the highest frequency amongst syndromic forms. Hypertensive disorders in pregnancy, developmental dysplasia of the hip, central nervous diseases and respiratory failure showed significant statistical associations (p <0.05) with syndromic forms. Conclusions: These data provide an epidemiological reference of Orofacial Clefts in Colombia. Novel associations between syndromic forms and clinical variables are determined. In order to investigate causality relationships between these variables further studies must be carried out.

Clinical aspects associated with syndromic forms of Orofacial Clefts in a Colombian population

Objectives: To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nested-series of cases. Methods: A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, and distribution of Orofacial Clefts according to sex and affected-side were determined. Odds ratios were calculated as measures of association between syndromic forms and antenatal high-risk conditions, preterm birth and comorbidities. A total of three hundred and eleven patients with Orofacial Clefts were assessed in a 12-month period. Results: The most frequent type of Orofacial Clefts was cleft lip and palate, this type of cleft was more frequent in males, whereas cleft palate occurred more often in females. The most common cases occurred as non-syndromic forms. Aarskog-Scott syndrome showed the highest frequency amongst syndromic forms. Hypertensive disorders in pregnancy, developmental dysplasia of the hip, central nervous diseases and respiratory failure showed significant statistical associations (p <0.05) with syndromic forms. Conclusions: These data provide an epidemiological reference of Orofacial Clefts in Colombia. Novel associations between syndromic forms and clinical variables are determined. In order to investigate causality relationships between these variables further studies must be carried out.

INFLUÊNCIA DA SAÚDE BUCAL SOBRE A QUALIDADE DE VIDA DE ADOLESCENTES ESCOLARES

Objetivo: Investigar o impacto da saúde bucal em relação à qualidade de vida de adolescentes escolares, associando-o às condições sociodemográficas. Métodos: Estudo de campo transversal e quantitativo desenvolvido em 2012, no município de Sumé-PB, com 184 adolescentes na faixa etária de 15 a 19 anos. Para avaliar o impacto, aplicou-se o questionário Oral Health Impact Profile (OHIP-14) aos participantes, enquanto para a obtenção dos dados referentes às condições sociodemográficas, os pais ou responsáveis responderam a um segundo questionário. Utilizou-se o teste Qui-quadrado para associar o impacto da saúde bucal sobre a qualidade de vida e as variáveis sociodemográficas pesquisadas, sendo considerados significativos com p<0,05. Resultados: Em geral, o impacto foi considerado fraco em 167 pesquisados (90,8%). “Dor física” foi a dimensão na qualidade de vida mais afetada pelas questões bucais entre aquelas que resultaram em impacto médio (22,8%; n=42). Apenas as variáveis “Situação do imóvel” e “Acomodação” associaram-se ao impacto geral (p<0,05). Os reduzidos percentuais de impacto geral forte (1,1%; n=2) relacionaram-se aos adolescentes cujas mães só estudaram até o ensino fundamental, ou às famílias que vivem com um salário mínimo ou menos (1,1%). Conclusão: Observou-se que as condições de saúde bucal apresentaram um impacto negativo fraco na qualidade de vida dos adolescentes investigados. As análises das condições sociodemográficas dos indivíduos relacionadas ao impacto geral da qualidade de vida relacionada à saúde oral associaram-se as variáveis “Situação do imóvel” e “Acomodação”.